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Arhewoh, Ikhuoria M.
- Evaluation of Two Techniques for the Production of Alginate-Based Microcapsules for Oral Delivery of Ibuprofen
Abstract Views :182 |
PDF Views:76
Authors
Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City 300001, NG
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City 300001, NG
Source
Journal of Pharmaceutical Research, Vol 8, No 1 (2009), Pagination: 19-23Abstract
A widely used approach for the microencapsulation of drugs especially for controlled drug delivery is emulsion polymerization. The purpose of this study was to comparatively evaluate chitosan-alginate microcapsules for oral delivery of ibuprofen using two techniques. Alginate-based microcapsules were prepared using the emulsion/internal gelation and electrostatic droplet generator/counter-ion coacervation methods. The effect of production parameters on the size of the microcapsules and in vitro ibuprofen release at pH 1.2 and 7.4 was determined. For emulsion/internal gelation method, the results showed that increase in stirring rate, volume of dispersion medium and viscosity of the coating materials did not significantly (p > 0.05) affect the size of the microcapsules. Microcapsules produced by the electrostatic droplets generator method had a narrower size distribution compared to the emulsion method. Drug release at pH 7.4 was considerably more than at pH 1.2, especially for uncoated microcapsules, microcapsules coated with high-viscosity (undigested) chitosan, and microcapsules prepared by the emulsion method. The encapsulation efficiencies of the two methods were similar as over 90% of ibuprofen was entrapped in each case. The two microencapsulation techniques can be applied in the microencapsulation of ibuprofen for oral delivery.Keywords
Droplet Generator, Emulsion Method, Ibuprofen, Microcapsules, Oral Delivery.- Protein Retention in Chitosan-Alginate Microcapsules Modified for Possible Oralprotein Deliverywith Selected Excipients
Abstract Views :167 |
PDF Views:74
Authors
Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City 300001, NG
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City 300001, NG